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干细胞/诱导多能干细胞研究产品

Maintains ES & iPS cells in an undifferentiated state & Improves reprogramming efficiency

Wako Cat. #

Description

Grade CAS No.

Unit

018-22521

A-83-01 TGF-β RI Kinase Inhibitor IV

For CellbiIology CAS 909910-43-6

2 mg

014-22523

ALK4, ALK5, ALK7 selective inhibitor

10 mg

Used to culture rat iPS cells uniformly in an undifferentiated state for a long period of time.

[Li, W.,et al.: Cell Stem Cell, 4, 16 (2009)]

013-22211

Adrenocorticotropic Hormone (1-24) (Human) ACTH

For Cellbiology

1 mg

Used to form single and undifferentiated mouse ES cell colonies.

CAS 16960-16-0

[Ogawa, K.,et al.: Genes Cells, 9, 471 (2004)]

012-23021

ALK5 Inhibitor TGF-β RI Kinase Inhibitor II

For Cellbiology

1 mg

Inhibitor of TGF-β RI Kinase/ALK5.

CAS 446859-33-2

[Maherali N., et al.: Curr. Biol., 19, 1718 (2009)]

027-09951

(±) Bay K8644 L type Ca2? Channel Agonist

For Biochemistry

5 mg

When used with Oct3/4 and Klf4, BayK8644 is able to culture iPS cells more efficiently.

CAS 71145-03-4

[Shi, Y., et al.: Cell Stem Cell, 3, 568 (2008)]

023-16401

BIX01294 Histone Methyltransferase inhibitor

For Cellbiology

2 mg

Enhances reprogramming efficiency of neural progenitor cells to the same levels as when Oct4, Klf4 were introduced to somatic cells for generation of iPS Cells.

CAS 935693-62-2

[Shi, Y., et al.: Cell Stem Cell, 2, 525 (2008)]

[Shi, Y., et al.: Cell Stem Cell, 3, 568 (2008)]

021-17041

(-)-Blebbistatin Specific inhibitor to miosin II A histone methyltransferase inhibitor. Enhances the efficiency of iPS cell induction when used during delivery of Oct3/4 and Klf4 to neural stem cells. Use of this product with (±)BayK8644 during delivery of Oct3/4 and Klf4 to fibroblasts also increases the efficiency of iPS cell induction. [Ohgushi, M., et al.: Cell Stem Cell, 7, 225 (2010)]

For Cellbiology

1 mg

027-17043

CAS 856925-71-8

5 mg

029-16241

6-Bromoindirubin-3’-oxime BIO】【GSK-3 Inhibitor IX

For Cellbiology

1 mg

Can maintain human and mouse ES cells in an undifferentiated state without feeder cells.

CAS 667463-62-9

Soluble in DMSO (1 mg/mL confirmed)

[Sato, N., et al.: Nature Med., 10, 55 (2004)]

029-05393

Butyric Acid

Wako Special Grade

25 mL

023-05396

Controls in cell proliferation through low cytotoxicity.

CAS 107-92-6

500 mL

[Liang, G., et al.: J. Biol. Chem., 285, 25516 (2010)]

032-22401

CHIR99021 CT99021 High selective GSK-3 Inhibitor

For Cellbiology

1 mg

038-22403

CHIR99021 is a GSK-3 b (Glycogen Synthase Kinase3b) inhibitor. A recent study has shown that mouse ES cells can be cultured efficiently in a medium containing PD184352, SU5402 and this product, CHIR99021. Another study has also shown that CHIR99021 increases the reprogramming efficiency from mouse neural stem cells to iPS cells.

CAS 252917-06-9

5 mg

[Ying, QL., et al.: Nature, 453, 519 (2008)]

035-22131

Cyclic Pifithrin-α Hydrobromide

for Cellbiology

5 mg

A reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription. A decrease in p53 activity enhances the reprogramming efficiency of human and mouse somatic cells.

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